Drugs used for acid reflux may increase body weight by an average of 3.5kg if taken long-term, according to a new study from Japan.

Proton pump inhibitors (PPIs) are a common drug for treating gastro-oesophageal reflux disease (GORD) but this latest study suggests they may lead to increased weight and Body Mass Index (BMI).

Fifty-two patients taking PPIs over 2 years were compared with a similar number of people of the same age and sex. Of those taking PPIs, 71% increased their weight with only 12% reducing their weight. There was also a significant increase in BMI from 23.1 to 24. In the control group, there were no increases.

Researchers suggest an explanation for the increase is down to an improvement in acid reflux symptoms when taking PPIs. This may increases appetite and allow patients to eat more.

‘Reflux patients treated with a daily maintenance therapy of PPI should be strongly encouraged to manage their body weight through lifestyle modifications such as proper diet and avoidance of overeating,’ they say.